Nail Changes During Docetaxel Containing Combination Chemotherapy

Nail Changes During Docetaxel Containing Combination Chemotherapy

Nail toxicity following systemic chemotherapy is common. Onychopathy during the period of neutropenia following chemotherapy may cause subungual abscesses and serious infection. Despite taxoid-related toxicity being increasingly reported since 2000, there are still phase II systemic chemotherapy studies using taxoid that have never mentioned nail changes. Recently, new criteria for the evaluati...

Nail changes secondary to docetaxel chemotherapy : a case report

INTRODUCTION Docetaxel is a chemotherapy agent used in the management of many neoplastic conditions. Various side effects are known. Nail changes are often under-recognised or attributed to other causes. CASE PRESENTATION We report the case of a 66 year old gentleman who received docetaxel chemotherapy for non-small cell lung cancer. He had nail changes as a complication of the treatment. C...

Nail changes after chemotherapy.

Trastuzumab–Docetaxel Combination Chemotherapy Induced Severe Onychopathy

Sir, Taxanes, which are inhibitors of tubulin function in mitosis and used as cancer chemotherapy, are well known to be associated with onychopathy. Trastuzumab, a recombinant DNA‐derived humanized monoclonal antibody against the human epidermal growth factor receptor 2 protein (HER‐2) is used in combination with taxanes in advanced stage HER‐2 positive metastatic breast cancer.[1] We report th...

Chemotherapy-induced nail changes: an unsightly nuisance.

P.S. is a 53-year-old female patient with stage IIB breast cancer. In November 2000, she received Adriamycin (Pfizer Inc., New York, NY) and Cytoxan (Bristol-Myers Squibb, New York, NY), along with Herceptin (Genentech, Inc., South San Francisco, CA), as part of a clinical trial. In July 2002, the patient was found to have a left supraclavicular axillary recurrence. Because of this recurrence, ...